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Figure 8d. IHS in a 3-month-old boy with erythematous rash over his entire body. The patient had persistent eosinophilia of 1600 cells per cubic millimeter for 12 months. (a) Initial chest radiograph shows bilateral diffuse ground-glass opacities. (b) High-resolution CT scan obtained the same day shows diffuse ground-glass opacities in both lungs. (c) High-power photomicrograph (original magnification, x400; H-E stain) of an open biopsy specimen obtained from the right lower lobe 1 month after b reveals infiltration of eosinophils into the alveoli and interstitium. Note the formation of indistinct granuloma (arrow). (d) High-power photomicrograph (original magnification, x400; H-E stain) of a percutaneous liver biopsy specimen obtained 1 month after b reveals eosinophil infiltration into the sinusoids. Bone marrow biopsy revealed normocellular marrow consisting of 18% eosinophils and no blast cells. (e, f) CT scans (5-mm collimation, lung windowing) obtained 5 months after b show multiple nodules in the left upper lobe (arrows).
