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Figure 3b. Iatrogenic Creutzfeldt-Jakob disease after a cadaveric dura mater transplantation in a 57-year-old woman. Images were obtained 7 weeks after the onset of progressive dementia and right hemiplegia and 4 weeks before the appearance of periodic synchronous discharges on the EEG. (a) Axial T2-weighted image shows no areas of abnormal signal intensity and only postoperative changes in the left parieto-occipital region. (b) Diffusion-weighted image shows areas of abnormal high signal intensity in the left cerebral cortex and the bilateral caudate nuclei. (c) Photomicrograph (original magnification, x20; hematoxylin and eosin stain) shows spongiform (vacuolar) degeneration of the gray matter neuropil in a specimen from the cerebral cortex.
