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Figure 13a. Increased bone marrow uptake due to G-CSF therapy and lymphomatous infiltration in a 30-year-old woman with relapsed Hodgkin disease. (a) Sagittal PET scan obtained prior to chemotherapy shows heterogeneous intense FDG uptake in the spine (arrows), a finding that suggests lymphomatous involvement. Note the relatively low uptake in the sternum and in several vertebrae (arrowheads). (b) On a sagittal PET scan obtained 2 months after chemotherapy, the previously involved bone marrow demonstrates decreased uptake (arrows), whereas the relatively normal bone marrow shows intense uptake due to G-CSF therapy (arrowheads).
