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Figure 5b. Thyroid nodule in a 51-year-old man with a history of squamous cell carcinoma of the tonsil who was referred for postsurgical evaluation. Axial PET scan (b) reveals a hypermetabolic focus in the right side of the neck (arrow) that is highly suspicious for metastatic disease. (a, c) Axial CT (a) and PET-CT fusion (c) images demonstrate that the focus (arrow) corresponds to the right thyroid lobe and is consistent with a thyroid nodule, a finding that was confirmed with subsequent ultrasonography. PET-CT findings confirmed that the patient did not have lymph node metastasis; however, a thyroid nodule requires further investigation with biopsy to rule out a malignant cause within the thyroid gland.