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DOI: 10.1148/rg.236035118
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Invited Commentary • Authors' Response

B. J. Manaster, MD, PhD

Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado



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Figure 1a.  Lateral (a) and anteroposterior (b) radiographs of the leg in a 35-year-old man. The marrow abnormality is barely discernible as a permeative pattern. The more prominent, but still subtle, abnormality is the endosteal thickening of the cortex, seen posteriorly on the lateral view and medially on the anteroposterior view. Results of biopsy of the marrow showed primary lymphoma of bone.

 


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Figure 1b.  Lateral (a) and anteroposterior (b) radiographs of the leg in a 35-year-old man. The marrow abnormality is barely discernible as a permeative pattern. The more prominent, but still subtle, abnormality is the endosteal thickening of the cortex, seen posteriorly on the lateral view and medially on the anteroposterior view. Results of biopsy of the marrow showed primary lymphoma of bone.

 


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Figure 2a.  Anteroposterior (a) and lateral (b) views of the midfemur in a 30-year-old woman. The lesion is quite permeative, and there is periosteal reaction. The presence of endosteal thickening, seen particularly posteriorly and medially, helps suggest the diagnosis of primary lymphoma of bone, which was confirmed at biopsy.

 


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Figure 2b.  Anteroposterior (a) and lateral (b) views of the midfemur in a 30-year-old woman. The lesion is quite permeative, and there is periosteal reaction. The presence of endosteal thickening, seen particularly posteriorly and medially, helps suggest the diagnosis of primary lymphoma of bone, which was confirmed at biopsy.

 


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Figure 3a.  (a) Anteroposterior radiograph of the left hip in a 31-year-old woman. A highly permeative lesion is seen to involve the superior acetabulum and extend to the ischium and superior pubic ramus. (b, c) T2-weighted MR images (2,700/104) obtained at the level of the ischium (b) and at the junction of the proximal and middle thirds of the thigh (c) demonstrate a high-signal-intensity soft-tissue mass that infiltrates surrounding muscle and extends far beyond the osseous involvement; multiple muscle compartments are involved. The long proximal and distal extent, coupled with the involvement of multiple compartments and invasiveness, distinguish this lesion from the round and more focal masses usually seen in osseous sarcomas, and suggest the diagnosis of primary lymphoma of bone.

 


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Figure 3b.  (a) Anteroposterior radiograph of the left hip in a 31-year-old woman. A highly permeative lesion is seen to involve the superior acetabulum and extend to the ischium and superior pubic ramus. (b, c) T2-weighted MR images (2,700/104) obtained at the level of the ischium (b) and at the junction of the proximal and middle thirds of the thigh (c) demonstrate a high-signal-intensity soft-tissue mass that infiltrates surrounding muscle and extends far beyond the osseous involvement; multiple muscle compartments are involved. The long proximal and distal extent, coupled with the involvement of multiple compartments and invasiveness, distinguish this lesion from the round and more focal masses usually seen in osseous sarcomas, and suggest the diagnosis of primary lymphoma of bone.

 


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Figure 3c.  (a) Anteroposterior radiograph of the left hip in a 31-year-old woman. A highly permeative lesion is seen to involve the superior acetabulum and extend to the ischium and superior pubic ramus. (b, c) T2-weighted MR images (2,700/104) obtained at the level of the ischium (b) and at the junction of the proximal and middle thirds of the thigh (c) demonstrate a high-signal-intensity soft-tissue mass that infiltrates surrounding muscle and extends far beyond the osseous involvement; multiple muscle compartments are involved. The long proximal and distal extent, coupled with the involvement of multiple compartments and invasiveness, distinguish this lesion from the round and more focal masses usually seen in osseous sarcomas, and suggest the diagnosis of primary lymphoma of bone.

 





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