Best Cases from the AFIP
Gastrointestinal Stromal Tumor1
Rebecca M. Sharp, MD,
Howard J. Ansel, MD and
Suzanne B. Keel, MD
1 From the Department of Radiology, University of Minnesota—Veterans Affairs Medical Center, 420 Delaware St SE Box 292, Minneapolis, MN 55455. Received June 28, 2001; revision requested August 10 and received August 27; accepted August 28. Address correspondence to R.M.S., 2835 Century Hills Ln NE, Rochester, MN 55906 (e-mail: sharp019@hotmail.com).
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Figure 1. Image from a double-contrast barium study demonstrates a round, smooth submucosal mass protruding into the gastric lumen along the greater curvature. The overlying mucosa appears to be intact.
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Figure 2a. Contrast-enhanced CT scans demonstrate the small intraluminal (a) and larger extraluminal (b) components of the mass (arrow), which demonstrates central low attenuation.
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Figure 2b. Contrast-enhanced CT scans demonstrate the small intraluminal (a) and larger extraluminal (b) components of the mass (arrow), which demonstrates central low attenuation.
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Figure 3a. (a) Photograph of the resected specimen reveals a large, lobulated mass that is primarily extraluminal in location. Only a small portion of the mass protrudes into the gastric lumen. The overlying mucosa is intact. (b) Photograph of the cut section reveals internal degenerative cystic changes in the mass, accounting for the central low attenuation seen at CT (cf Fig 2).
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Figure 3b. (a) Photograph of the resected specimen reveals a large, lobulated mass that is primarily extraluminal in location. Only a small portion of the mass protrudes into the gastric lumen. The overlying mucosa is intact. (b) Photograph of the cut section reveals internal degenerative cystic changes in the mass, accounting for the central low attenuation seen at CT (cf Fig 2).
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Figure 4a. (4a) Photomicrograph (original magnification, x40; hematoxylin-eosin stain) demonstrates a cellular focus of tumor composed of spindle cells that are somewhat haphazardly arranged. (4b) Higher-power photomicrograph (original magnification, x200; hematoxylin-eosin stain) shows that the spindle cells contain a moderate amount of eosinophilic cytoplasm. Necrosis is not present.
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Figure 4b. (4a) Photomicrograph (original magnification, x40; hematoxylin-eosin stain) demonstrates a cellular focus of tumor composed of spindle cells that are somewhat haphazardly arranged. (4b) Higher-power photomicrograph (original magnification, x200; hematoxylin-eosin stain) shows that the spindle cells contain a moderate amount of eosinophilic cytoplasm. Necrosis is not present.
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Figure 5. Photomicrograph (CD34 immunostain) demonstrates diffuse dark brown staining of the cytoplasm, indicating CD34 positivity of the tumor cells.
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Copyright © 2001 by the Radiological Society of North America.
