Oncodiagnosis Panel: 1997
Prostatic Carcinoma
Colleen A. Lawton, MD1,
David Grignon, MD2,
Jeffrey H. Newhouse, MD3,
Paul F. Schellhammer, MD4 and
Deborah A. Kuban, MD4
1 Departments of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 (C.A.L.)
2 Pathology, Harper Hospital, Detroit, Mich (D.G.)
3 Radiology, Columbia Presbyterian Medical Center, New York, NY (J.H.N)
4 Radiation Oncology, Eastern Virginia Medical School, Norfolk, Va (P.F.S., D.A.K.).
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Figure 1. Figures 1–3 (1) Gleason grade 2 adenocarcinoma. Photomicrograph shows a tumor composed of well-formed round glands growing in a relatively circumscribed nodule. (2) Gleason grade 3 adenocarcinoma. Photomicrograph shows a tumor composed of uniform small glands that are growing in an infiltrative pattern. (3) Gleason grade 4 adenocarcinoma. Photomicrograph of a needle biopsy specimen shows the tumor growing as solid fused glands. A benign gland is seen in the center.
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Figure 2. Figures 1–3 (1) Gleason grade 2 adenocarcinoma. Photomicrograph shows a tumor composed of well-formed round glands growing in a relatively circumscribed nodule. (2) Gleason grade 3 adenocarcinoma. Photomicrograph shows a tumor composed of uniform small glands that are growing in an infiltrative pattern. (3) Gleason grade 4 adenocarcinoma. Photomicrograph of a needle biopsy specimen shows the tumor growing as solid fused glands. A benign gland is seen in the center.
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Figure 3. Figures 1–3 (1) Gleason grade 2 adenocarcinoma. Photomicrograph shows a tumor composed of well-formed round glands growing in a relatively circumscribed nodule. (2) Gleason grade 3 adenocarcinoma. Photomicrograph shows a tumor composed of uniform small glands that are growing in an infiltrative pattern. (3) Gleason grade 4 adenocarcinoma. Photomicrograph of a needle biopsy specimen shows the tumor growing as solid fused glands. A benign gland is seen in the center.
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Figure 4a. (a) Follow-up bone scan reveals a region of intense activity (arrow) in the lumbar spine. (b) Axial CT scan reveals blastic regions (arrow) at same location. (c) Sagittal T1-weighted MR image reveals a low-signal-intensity lesion (arrow) in the vertebral body.
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Figure 4b. (a) Follow-up bone scan reveals a region of intense activity (arrow) in the lumbar spine. (b) Axial CT scan reveals blastic regions (arrow) at same location. (c) Sagittal T1-weighted MR image reveals a low-signal-intensity lesion (arrow) in the vertebral body.
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Figure 4c. (a) Follow-up bone scan reveals a region of intense activity (arrow) in the lumbar spine. (b) Axial CT scan reveals blastic regions (arrow) at same location. (c) Sagittal T1-weighted MR image reveals a low-signal-intensity lesion (arrow) in the vertebral body.
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Figure 5. Mucinous type of prostatic adenocarcinoma. Photomicrograph shows a tumor composed of small glands and nests of cells floating in a background of extravasated mucin.
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Figure 6. Ductal type of prostatic adenocarcinoma. Photomicrograph shows a tumor growing with a papillary architecture with pseudostratified, tall columnar tumor cells that have large vesicular nuclei with macronucleoli.
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Figure 7. Small cell carcinoma of the prostate. Photomicrograph shows a tumor composed of cells with small hyperchromatic nuclei that have granular chromatic and inconspicuous nucleoli. There is scant cytoplasm, and the cells do not form any glandular structures.
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Figure 8. Axial CT scan of the pelvis reveals a lytic bone metastasis (arrow) at a site identical to the region of radionuclide uptake seen on the bone scan.
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Figure 9a. (a) Axial CT scan obtained 6 months later reveals multiple low-attenuation hepatic lesions consistent with metastatic disease. (b) Axial CT scan of the chest shows multiple peripheral pulmonary nodules (arrows).
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Figure 9b. (a) Axial CT scan obtained 6 months later reveals multiple low-attenuation hepatic lesions consistent with metastatic disease. (b) Axial CT scan of the chest shows multiple peripheral pulmonary nodules (arrows).
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Figure 10a. (a) Image from a bone scan study (anterior view on left; posterior on right) reveals increased uptake in the spine, hips, shoulders, knees, and posterior left rib. (b) Image from another bone scan study performed 2 years later reveals more florid increased uptake in the spine, ribs, shoulders, pelvis, knees, and left femur.
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Figure 10b. (a) Image from a bone scan study (anterior view on left; posterior on right) reveals increased uptake in the spine, hips, shoulders, knees, and posterior left rib. (b) Image from another bone scan study performed 2 years later reveals more florid increased uptake in the spine, ribs, shoulders, pelvis, knees, and left femur.
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Copyright © 1999 by the Radiological Society of North America.
