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Multimodality Imaging of Hodgkin Disease and Non-Hodgkin Lymphomas in Children¹

¹ From the Departments of Radiology (P.T., C.G.), Neuroradiology (A.R.), and Oncology (A.G.), Giannina Gaslini Children’s Hospital, Largo Gaslini 5, 16147 Genoa, Italy. Presented as an education exhibit at the 2005 RSNA Annual Meeting. Received August 24, 2006; revision requested November 14 and received February 28, 2007; accepted March 26. All authors have no financial relationships to disclose. Address correspondence to C.G. (e-mail: cgranata{at}sirm.org).

Lymphomas account for 10%–15% of all childhood cancers and include a number of different pathologic subtypes, which arise from the constituent cells of the immune system or from their precursors. All organ systems may be involved at some stage of the disease, including the central nervous system, head and neck, thorax, abdomen, gonads, and bone. However, at onset, nodal and splenic involvement are more common in Hodgkin disease, whereas extranodal involvement is more frequent in non-Hodgkin lymphomas. Diagnostic imaging modalities have a fundamental role in the staging of lymphomas and, owing to major advances during the past two decades, make surgical staging unnecessary in most cases. Conventional, sonographic, and cross-sectional imaging techniques are excellent tools for evaluating the extent and sites of disease in childhood lymphomas. Familiarity with the spectrum of imaging findings in lymphomas is essential for radiologists to enable them to provide guidance for the treating physicians.

© RSNA, 2007

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