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DOI: 10.1148/rg.26si065513
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RadioGraphics 2006;26:S173-S189
© RSNA, 2006

Advanced MR Imaging Techniques in the Diagnosis of Intraaxial Brain Tumors in Adults1

Riyadh N. Al-Okaili, MD, Jaroslaw Krejza, MD, PhD2, Sumei Wang, MD, John H. Woo, MD and Elias R. Melhem, MD, PhD

1 From the Department of Radiology, University of Pennsylvania School of Medicine, 3400 Spruce St, Dulles 2, Philadelphia, PA 19104. Received May 17, 2006; revision requested June 14 and received July 10; accepted July 13. All authors have no financial relationships to disclose. Address correspondence to E.R.M. (e-mail: Elias.Melhem{at}uphs.upenn.edu).

Intraaxial brain masses are a significant health problem and present several imaging challenges. The role of imaging is no longer limited to merely providing anatomic details. Sophisticated magnetic resonance (MR) imaging techniques allow insight into such processes as the freedom of water molecule movement, the microvascular integrity and hemodynamic characteristics, and the chemical makeup of certain compounds of masses. The role of the most commonly used advanced MR imaging techniques—perfusion imaging, diffusion-weighted imaging, and MR spectroscopy—in the diagnosis and classification of the most common intraaxial brain tumors in adults is explored. These lesions include primary neoplasms (high- and low-grade), secondary (meta-static) neoplasms, lymphoma, tumefactive demyelinating lesions, abscesses, and encephalitis. Application of a diagnostic algorithm that integrates advanced MR imaging features with conventional MR imaging findings may help the practicing radiologist make a more specific diagnosis for an intraaxial tumor.

© RSNA, 2006




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R. N. Al-Okaili, J. Krejza, J. H. Woo, R. L. Wolf, D. M. O'Rourke, K. D. Judy, H. Poptani, and E. R. Melhem
Intraaxial Brain Masses: MR Imaging-based Diagnostic Strategy--Initial Experience
Radiology, May 1, 2007; 243(2): 539 - 550.
[Abstract] [Full Text] [PDF]


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