HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) CME Test (opens in a new window) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Robertson, M. B. Articles by Joseph, P. M. Search for Related Content PubMed PubMed Citation Articles by Robertson, M. B. Articles by Joseph, P. M. Related Collections Gastrointestinal Radiology Genitourinary Radiology

Review of the Abdominal Manifestations of Cystic Fibrosis in the Adult Patient¹

¹ From the Departments of Radiology (M.B.R., K.A.C.) and Internal Medicine (P.M.J.), University of Cincinnati, 234 Goodman St, ML 0761, Cincinnati, OH 45267-0761. Presented as an education exhibit at the 2004 RSNA Annual Meeting. Received April 25, 2005; revision requested May 24 and received July 15; accepted July 20. All authors have no financial relationships to disclose. Address correspondence to K.A.C. (e-mail: choeka{at}email.uc.edu).

Cystic fibrosis is a common inherited fatal disease. As the life expectancy of affected individuals continues to increase with advances in disease management, this disease is no longer limited to the pediatric population. Currently, 40% of patients with cystic fibrosis are adults. In addition, patients may not present until adulthood and frequently have extrapulmonary symptoms. Abdominal manifestations are common and affect multiple organ systems. Hepatobiliary manifestations include fatty infiltration of the liver, gallbladder abnormalities, bile duct abnormalities, focal biliary fibrosis, and multinodular cirrhosis. Manifestations in the pancreas include acute pancreatitis, fatty replacement, calcifications, cysts, duct abnormalities, and carcinoma. Gastrointestinal manifestations include gastroesophageal reflux, peptic ulceration of the gastric and duodenal mucosa, distal intestinal obstruction syndrome, intussusception, appendicitis, fibrosing colonopathy, pneumatosis intestinalis, rectal mucosal prolapse, malignancies, and pseudomembranous colitis. Renal manifestations include nephrolithiasis, as well as secondary renal complications such as interstitial nephritis due to antibiotic therapy and amyloidosis. Awareness of these manifestations is important to successfully guide management of cystic fibrosis in adult patients.

© RSNA, 2006

This article has been cited by other articles:

				I. Schrijver, K. Rappahahn, L. Pique, M. Kharrazi, and L.-J. Wong Multiplex Ligation-Dependent Probe Amplification Identification of Whole Exon and Single Nucleotide Deletions in the CFTR Gene of Hispanic Individuals with Cystic Fibrosis J. Mol. Diagn., July 1, 2008; 10(4): 368 - 375. [Abstract] [Full Text] [PDF]

				M. Wilschanski and P. R Durie Patterns of GI disease in adulthood associated with mutations in the CFTR gene Gut, August 1, 2007; 56(8): 1153 - 1163. [Full Text] [PDF]

				H. P. Haber Cystic Fibrosis in Children and Young Adults: Findings on Routine Abdominal Sonography Am. J. Roentgenol., July 1, 2007; 189(1): 89 - 99. [Abstract] [Full Text] [PDF]