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Informatics in Radiology (infoRAD)

Magnetic Resonance Imaging Workbench: Analysis and Visualization of Dynamic Contrast-enhanced MR Imaging Data¹

¹ From the Cancer Research UK Clinical MR Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, United Kingdom SM2 5PT (J.A.D., D.J.C., S.W.S., M.O.L.); the Department of Radiology, Mount Vernon Hospital, North-wood, Middlesex, England (A.R.P.); and the Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, England (J.S.). Presented as an infoRAD exhibit at the 2003 RSNA Annual Meeting. Received July 19, 2005; revision requested October 13 and received November 11; accepted December 6. J.A.D., D.J.C., and M.O.L. may benefit financially from the licensing and commercialization of the MRIW software; A.R.P. has used the MRIW software to analyze results of commercially sponsored clinical drug trials; the other authors have no financial relationships to disclose. Supported by grant C1060/A808 from Cancer Research UK. Address correspondence to J.A.D. (e-mail: jamesd{at}icr.ac.uk).

Magnetic Resonance Imaging Workbench (MRIW) allows analysis of T1- and T2*-weighted dynamic contrast-enhanced magnetic resonance imaging data sets to extract tissue permeability and perfusion characteristics by using standard pharmacokinetic models. Parametric maps are calculated from individual pixel enhancement curves in regions of interest (ROIs) and displayed as color overlays on the anatomic images. User-defined ROIs can be saved to ensure consistency of later reanalysis. Individual parametric maps are visualized together with user-selected parameter time-series plots. The following selections are available: overall ROI enhancement curve and fit, histogram, and individual pixel enhancement curve and fit. Summary data (transfer constant, leakage space, rate constant, integrated area under the gadolinium curve after 60 seconds, relative blood volume, relative blood flow, and mean transit time) may be exported to permanent storage along with per-pixel results for statistical analysis. Numerical values for parameters are displayed below the plot for easy reference. The dynamic range of plots and parametric map overlays is interactively adjustable. Viewing individual enhancement curves and parametric maps allows radiologists to investigate the heterogeneity of contrast agent kinetics for lesion characterization and to scrutinize serial changes in response to therapy. MRIW is written in IDL, enabling it to be used on a variety of computer systems.

© RSNA, 2006

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