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Multi–Detector Row CT of Pancreatic Islet Cell Tumors¹

¹ From the Russell H. Morgan Department of Radiology and Radiological Sciences (K.M.H., E.K.F.), the Department of Pathology (R.H.H.), and the Department of Surgery (C.Y.), Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC 3253, Baltimore, MD 21287. Presented as an education exhibit at the 2004 RSNA Annual Meeting. Received March 18, 2005; revision requested May 9 and received July 14; accepted July 20. All authors have no financial relationships to disclose. Address correspondence to K.M.H. (e-mail: kmhorton{at}jhmi.edu).

Pancreatic islet cell tumors (ICTs) are neuroendocrine neoplasms that produce and secrete hormones to a variable degree. These neoplasms can present a diagnostic challenge, both clinically and radiologically. ICTs can be classified as either syndromic or nonsyndromic on the basis of their clinical manifestations. Multi–detector row computed tomography (CT) plays an important role in the diagnosis and staging of both syndromic and nonsyndromic ICTs. In general, syndromic ICTs are less than 3 cm in size. They are typically hyperenhancing and are usually best seen on CT scans obtained during the arterial phase. Nonsyndromic ICTs tend to be larger than syndromic ICTs at presentation and are more likely to be cystic or necrotic. It is important for the radiologist to be familiar with appropriate CT protocol for the evaluation of patients with suspected pancreatic ICT and to understand the variable CT appearances of these neoplasms.

© RSNA, 2006

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