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EDUCATION EXHIBIT |
1 From the Department of Radiology, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (T.K., H.U.); and the Departments of Diagnostic and Interventional Imageology (K.T.), Nuclear Medicine and Diagnostic Imaging (S.U., M.K.), and Respiratory Medicine (S.N.), Graduate School of Medicine, Kyoto University of Medicine, Kyoto, Japan. Recipient of a Certificate of Merit award for an education exhibit at the 2002 RSNA scientific assembly. Received March 21, 2003; revision requested April 23 and received August 28; accepted August 28. All authors have no financial relationships to disclose. Address correspondence to T.K. (e-mail: montpeti@kuhp.kyoto-u.ac.jp).
Sarcoidosis is a systemic disorder of unknown cause with a wide variety of clinical and radiologic manifestations. The diagnosis is usually made on the basis of these manifestations supported by histologic findings. Systemic manifestations (eg, Löfgren syndrome, Heerfordt syndrome) are commonly seen at clinical examination. Bilateral hilar lymphadenopathy is the most common radiologic finding—frequently with associated pulmonary infiltrates—and typically has a characteristic perivascular distribution at high-resolution chest computed tomography. Radiologic findings in the short tubular bones of the hands and feet and magnetic resonance imaging findings of nodular involvement of muscle are often sufficient to raise suspicion for sarcoidosis. In the liver, spleen, kidneys, and scrotum, coalescing granulomas form nodules whose imaging features may occasionally be nonspecific, although familiarity with the relevant clinical settings will be helpful in recognizing the presence of sarcoidosis. Radiologic recognition of cardiac and central nervous system involvement is also important because patients may be only mildly symptomatic. The clinical course and prognosis of sarcoidosis are highly variable, often correlating with the mode of onset. Familiarity with the clinical and radiologic features of sarcoidosis in various anatomic locations plays a crucial role in diagnosis and management.
© RSNA, 2004
Index Terms: Abdomen, diseases, 70.22, 76.22, 77.22, 81.22, 847.22 • Head and neck, 20.22 • Nervous system, diseases, 10.22, 30.22 • Sarcoidosis, **.222 • Thorax, diseases, 51.22, 60.22, 679.22
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