| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AFIP Archives |
1 From the Departments of Radiologic Pathology (G.J.L., C.M.S.) and Pediatric Pathology (E.S.S.), Armed Forces Institute of Pathology, 14th and Alaska Sts, NW, Bldg 54, Rm M-121, Washington, DC 20306-6000 and the Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md (G.J.L., C.C.). Received February 1, 2002; revision requested March 11 and received March 22; accepted March 22. Address correspondence to G.J.L. (e-mail: lonergan@afip.osd.mil).
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma are tumors of the sympathetic nervous system that arise from primitive sympathogonia and are referred to collectively as neuroblastic tumors. They arise wherever sympathetic tissue exists and may be seen in the neck, posterior mediastinum, adrenal gland, retroperitoneum, and pelvis. The three tumors differ in their degree of cellular and extracellular maturation; immature tumors tend to be aggressive and occur in younger patients (median age, just under 2 years), whereas mature tumors occur in older children (median age, approximately 7 years) and tend to behave in a benign fashion. The most benign tumor is the ganglioneuroma, which is composed of gangliocytes and mature stroma. Ganglioneuroblastoma is composed of both mature gangliocytes and immature neuroblasts and has intermediate malignant potential. Neuroblastoma is the most immature, undifferentiated, and malignant tumor of the three. Neuroblastoma, however, may have a relatively benign course, even when metastatic. Thus, these neuroblastic tumors vary widely in their biologic behavior. Features such as DNA content, tumor proto-oncogenes, and catecholamine synthesis influence prognosis, and their presence or absence aids in categorizing patients as high, intermediate, or low risk. Treatment consists of surgery and, usually, chemotherapy. Despite recent advances in treatment, including bone marrow transplantation, neuroblastoma remains a relatively lethal tumor, accounting for 10% of pediatric cancers but 15% of cancer deaths in children.
© RSNA, 2002
Index Terms: Nervous system, neoplasms, 6.3162, 6.3251, 8.3199, 8.325 • Neuroblastoma, 6.3251, 8.325 • Neuroma, 6.3162, 8.3199, 8.325
This article has been cited by other articles:
|
|
 |
|
  P. Bougneres, L. Pantalone, A. Linglart, A. Rothenbuhler, and C. Le Stunff Endocrine Manifestations of the Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neural Tumor Syndrome in Childhood J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3971 - 3980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Restrepo, A. Eraso, D. Ocazionez, J. Lemos, S. Martinez, and D. F. Lemos The Diaphragmatic Crura and Retrocrural Space: Normal Imaging Appearance, Variants, and Pathologic Conditions RadioGraphics, September 1, 2008; 28(5): 1289 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Chung, M. D. Murphey, C. S. Specht, R. Cube, and J. Smirniotopoulos From the Archives of the AFIP * Pediatric Orbit Tumors and Tumorlike Lesions: Osseous Lesions of the Orbit RadioGraphics, July 1, 2008; 28(4): 1193 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Rivard and L. H. Lowe Radiological Reasoning: Multiple Hepatic Masses in an Infant Am. J. Roentgenol., June 1, 2008; 190(6_Supplement): S46 - S52. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Palotas, G. Bogats, M. Lazar, M. Papos, K. Matin, and L. Pavics An Isotope-Diagnostic Approach to Erdheim-Chester's Disease of the Heart Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2006; 11(4): 274 - 279. [Abstract] [PDF]
|
|
|
|
|
|
M. Kocaoglu and D. P. Frush Pediatric presacral masses. RadioGraphics, May 1, 2006; 26(3): 833 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Lora, S. G. Waguespack, J. F. Moley, and E. C. Walvoord Adrenal Ganglioneuromas in Children with Multiple Endocrine Neoplasia Type 2: A Report of Two Cases J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4383 - 4387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J Hanna, A Muneer, S B Coghill, and M A W Miller Ganglioneuromas in the adult scrotum J R Soc Med, February 1, 2005; 98(2): 63 - 64. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Woodward, R. Sohaey, A. Kennedy, and K. K. Koeller From the Archives of the AFIP: A Comprehensive Review of Fetal Tumors with Pathologic Correlation RadioGraphics, January 1, 2005; 25(1): 215 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Elsayes, G. Mukundan, V. R. Narra, J. S. Lewis Jr, A. Shirkhoda, A. Farooki, and J. J. Brown Adrenal Masses: MR Imaging Features with Pathologic Correlation RadioGraphics, October 1, 2004; 24(suppl_1): S73 - S86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. J. Glass, S. K. Fernbach, K. I. Norton, P. S. Choi, and T. P. Naidich The Infant Skull: A Vault of Information RadioGraphics, March 1, 2004; 24(2): 507 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Forsythe, J. Volpe, and R. Muller Posterior Mediastinal Ganglioneuroma RadioGraphics, March 1, 2004; 24(2): 594 - 597. [Full Text] [PDF]
|
|
|
|
|
|
U. Tateishi, G. W. Gladish, M. Kusumoto, T. Hasegawa, R. Yokoyama, R. Tsuchiya, and N. Moriyama Chest Wall Tumors: Radiologic Findings and Pathologic Correlation: Part 2. Malignant Tumors RadioGraphics, November 1, 2003; 23(6): 1491 - 1508. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOGRAPHICS | RADIOLOGY | RSNA JOURNALS ONLINE |
