HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) CME Test (opens in a new window) Submit a response View responses Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guermazi, A. Articles by Frija, J. Search for Related Content PubMed PubMed Citation Articles by Guermazi, A. Articles by Frija, J. Related Collections General

Extranodal Hodgkin Disease: Spectrum of Disease¹

¹ From the Department of Radiology (A.G., E.d.K., J.F.), the Department of Hematology (P.B.), GELA, the Hayem Center of Hematology (C.F.), the Department of Radiation Therapy (C.H.), and the Department of Histopathology (V.M.), Saint-Louis Hospital, AP-HP, 1 Avenue Claude Vellefaux, 75475 Paris, France. Presented as a scientific exhibit at the 1999 RSNA scientific assembly. Received March 7, 2000; revision requested April 6 and received June 7; accepted June 9. Address correspondence to A.G. (e-mail: guermazi@chu-stlouis.fr).

Extranodal lesions in Hodgkin disease may develop and spread to virtually any organ system, simulating other neoplastic or infectious diseases. It is important to determine whether extranodal involvement represents a primary manifestation or dissemination of systemic disease, which has a poorer prognosis. Computed tomography (CT) is the preferred modality, although ultrasonography and magnetic resonance (MR) imaging may also be helpful. CT is superior to conventional radiography in assessing chest disease, although MR imaging is more sensitive than CT in detecting chest wall involvement. CT is preferred for evaluating hepatic lymphoma and has proved particularly valuable in diagnosing gastric lymphoma and detecting renal or perirenal masses. CT and MR imaging are equally effective in detecting brain Hodgkin disease; however, the latter is superior in the detection of extracerebral tumor deposits in the subdural or epidural space. MR imaging is also preferred for evaluating meningeal and spinal cord involvement. Both MR imaging and CT allow excellent assessment of bone texture and accurate analysis of tumoral bone invasion, but MR imaging is superior in demonstrating bone marrow infiltration, and CT is superior in delineating the extent of cortical bone destruction. In the future, metabolic positron emission tomography may provide more information about extranodal lymphoma than do the current imaging modalities.

Index Terms: Hodgkin disease, CT, **.1211 • Hodgkin disease, diagnosis, **.342² • Hodgkin disease, MR, **.12141 • Hodgkin disease, staging, **.342 • Hodgkin disease, therapy, **.342

This article has been cited by other articles:

				C. G. Cronin, D. G. Lohan, J. N. Mhuircheartaigh, D. McKenna, N. Alhajeri, C. Roche, and J. M. Murphy MRI Small-Bowel Follow-Through: Prone Versus Supine Patient Positioning for Best Small-Bowel Distention and Lesion Detection Am. J. Roentgenol., August 1, 2008; 191(2): 502 - 506. [Abstract] [Full Text] [PDF]

				W.-K. Lee, E. W. F. Lau, V. A. Duddalwar, A. J. Stanley, and Y. Y. Ho Abdominal Manifestations of Extranodal Lymphoma: Spectrum of Imaging Findings Am. J. Roentgenol., July 1, 2008; 191(1): 198 - 206. [Abstract] [Full Text] [PDF]

				V. R. Surabhi, C. Menias, S. R. Prasad, A. H. Patel, A. Nagar, and N. C. Dalrymple Neoplastic and Non-neoplastic Proliferative Disorders of the Perirenal Space: Cross-sectional Imaging Findings RadioGraphics, July 1, 2008; 28(4): 1005 - 1017. [Abstract] [Full Text] [PDF]

				R. Sinha, C. Nwokolo, and P. D Murphy Magnetic resonance imaging in Crohn's disease BMJ, February 2, 2008; 336(7638): 273 - 276. [Full Text] [PDF]

				N. P. Leite, N. Kased, R. F. Hanna, M. A. Brown, J. M. Pereira, R. Cunha, and C. B. Sirlin Cross-sectional Imaging of Extranodal Involvement in Abdominopelvic Lymphoproliferative Malignancies RadioGraphics, November 1, 2007; 27(6): 1613 - 1634. [Abstract] [Full Text] [PDF]

				E. Morawa, A. Ragam, R. Sirota, and C. Nabhan Hodgkin's Lymphoma Involving the CNS J. Clin. Oncol., April 10, 2007; 25(11): 1437 - 1438. [Full Text] [PDF]

				S. Sheth, S. Ali, and E. Fishman Imaging of renal lymphoma: patterns of disease with pathologic correlation. RadioGraphics, July 1, 2006; 26(4): 1151 - 1168. [Abstract] [Full Text] [PDF]

				H. Arslan, O. Etlik, M. Kayan, M. Harman, Y. Tuncer, and O. Temizoz Peroral CT Enterography with Lactulose Solution: Preliminary Observations Am. J. Roentgenol., November 1, 2005; 185(5): 1173 - 1179. [Abstract] [Full Text] [PDF]

				E. Even-Sapir Imaging of Malignant Bone Involvement by Morphologic, Scintigraphic, and Hybrid Modalities J. Nucl. Med., August 1, 2005; 46(8): 1356 - 1367. [Abstract] [Full Text] [PDF]

				B. Ferdinand, P. Gupta, and E. L. Kramer Spectrum of Thymic Uptake at 18F-FDG PET RadioGraphics, November 1, 2004; 24(6): 1611 - 1616. [Abstract] [Full Text] [PDF]

				S. C. Jacoby, D. J. Addrizzo-Harris, and H. Yee Respiratory Failure in a Patient with Hodgkin's Lymphoma Transforming into an Aggressive Syncytial Variant Infiltrating the Lung Chest Meeting Abstracts, October 1, 2004; 126(4): 938S - 939S. [Abstract] [Full Text] [PDF]

				O. Israel, M. Mekel, R. Bar-Shalom, R. Epelbaum, N. Hermony, N. Haim, E. J. Dann, A. Frenkel, M. Ben-Arush, and D. Gaitini Bone Lymphoma: 67Ga Scintigraphy and CT for Prediction of Outcome After Treatment J. Nucl. Med., October 1, 2002; 43(10): 1295 - 1303. [Abstract] [Full Text] [PDF]

eLetters: