Figure 8e. IHS in a 3-month-old boy with erythematous rash over his entire body. The patient had persistent eosin-ophilia of 1600 cells per cubic millimeter for 12 months. (a) Initial chest radiograph shows bilateral diffuse ground-glass opacities. (b) High-resolution CT scan obtained the same day shows diffuse ground-glass opacities in both lungs. (c) High-power photomicrograph (original magnification, x400; H-E stain) of an open biopsy specimen obtained from the right lower lobe 1 month after b reveals infiltration of eosinophils into the alveoli and interstitium. Note the formation of indistinct granuloma (arrow). (d) High-power photomicrograph (original magnification, x400; H-E stain) of a percutaneous liver biopsy specimen obtained 1 month after b reveals eosinophil infiltration into the sinusoids. Bone marrow biopsy revealed normocellular marrow consisting of 18% eosinophils and no blast cells. (e, f) CT scans (5-mm collimation, lung windowing) obtained 5 months after b show multiple nodules in the left upper lobe (arrows).