Figure 6b. Noguchi type E adenocarcinoma (tubular adenocarcinoma) in a 53-year-old man. (a) Transaxial thin-section (1-mm collimation) CT scan (lung window) obtained at the level of the bronchus intermedius shows a 22-mm nodule with a spiculated margin in the right upper lobe straddling the right minor fissure (arrows). (b) Low-power photomicrograph (original magnification, x12; H-E stain) of a surgical specimen shows a lobulated solid mass with no acinar structure. The surgical specimens showed no hilar or mediastinal nodal metastasis, but brain metastasis was seen at follow-up magnetic resonance (MR) imaging performed 2 years after surgery.