Figure 12b. PLCH in a 31-year-old man with cough, anorexia, weight loss, and a 15 pack-year history of cigarette smoking. (a) High-resolution CT scan (lung window) shows nodules and thick- and thin-walled cysts. Some nodules exhibit a centrilobular distribution. (b) Low-power photomicrograph (original magnification, x12; H-E stain) demonstrates a cellular nodule with stellate peripheral extensions into adjacent alveolar walls. (c) Low-power photomicrograph (original magnification x30; H-E stain) shows one of the cystic lesions produced by bronchiolar dilatation. Note the surrounding paracicatricial air-space enlargement (**).