Figure 1d. Gross pathologic and histologic features of classic FNH. (a) Cross section of a resected specimen of classic FNH shows yellowish nodules of variable size (straight black arrows) surrounded by multiple septa (arrowhead) and a central scar (*). The central scar contains large vessels (curved black arrow). Normal liver tissue (white arrow) surrounds the FNH. Note that there is no fibrous capsule at the interface of the lesion and the liver. (b) Photomicrograph (original magnification, x40; hematoxylin-eosin [H-E] stain) shows the interface of the FNH (*), which contains multiple nodules and septa, and the surrounding normal hepatic parenchyma, which contains large vessels (straight arrow) and portal vein tracts with inflammatory infiltrates (curved arrow). (c) Photomicrograph (original magnification, x40; H-E stain) shows a septum (arrow) dividing two neighboring nodules. The septum contains connective tissue and multiple arteries. (d) Photomicrograph (original magnification, x100; H-E stain) shows a typical FNH nodule (*) surrounded by septa. At the interface of the nodule and the septa, ductular proliferation can be seen (arrows).