Figure 7d. Osteosarcoma after bilateral retinoblastoma. (a, b) Axial T2-weighted (a) and contrast-enhanced fat-saturated T1-weighted (b) MR images obtained in an 8-month-old boy with leukocoria show extensive bilateral retinal tumors (arrows). (c) Follow-up contrast-enhanced CT scan obtained postoperatively shows residual soft tissue in the left orbit and an ocular prosthesis in the right orbit, without evidence of tumor. (d, e) CT scans obtained 4 years later (e obtained caudad to d) demonstrate a maxillary mass with bone destruction and matrix mineralization. Follow-up MR imaging performed after chemotherapy and radical surgery demonstrated no tumor recurrence.