Figure 2b. Nonspecific interstitial pneumonia in a 74-year-old woman. (a) High-resolution CT scan demonstrates bilateral, subpleural ground-glass attenuation. There are irregular linear areas of high attenuation (arrowhead) and evidence of architectural lung distortion with distortion of the left fissure (arrow). Follow-up CT in 7 months demonstrated no interval change. (b) Photomicrograph (original magnification, x12.5; hematoxylin-eosin stain) reveals alveolar architecture that is altered by interstitial fibrosis (a), all of which is approximately the same age. (c) Photomicrograph (original magnification, x50; hematoxylin-eosin stain) shows alveolar walls that are thickened by chronic inflammation (b) and fibrillar collagen (c).