Figure 2. Photomicrograph (original magnification, x180; hematoxylineosin stain) of a ganglioglioma shows a continuum of neuronal elements, including a multinucleated variant (arrow), within a well-differentiated spindled glial matrix that resembles pilocytic astrocytoma. Nissl substance (arrowheads) is present in the cytoplasm of a large neuron.