Figure 8. Amiodarone-associated thyroid disease in a 60-year-old man who complained of extreme fatigue, weight gain, and depression. Several weeks earlier during hospitalization for arrhythmias, the patient had been placed on amiodarone and was now clinically hypothyroid. At the time of imaging, total T4 was 3.3 µg/dL, T3 was 119 ng/dL, and TSH was 96 µIU/mL. The 24-hour RAIU was 4%. Anterior image shows an enlarged, nonuniform thyroid with overall decreased radiotracer concentration (arrow). Because of the high iodine content of amiodarone, patients taking the drug will have low RAIU.