Figure 12c. Cerebral aspergillosis with intralesional hemorrhage in a 55-year-old woman who presented with severe neurologic deficit. (a, b) Unenhanced (a) and contrast-enhanced (b) CT scans demonstrate the delayed appearance of bifrontal hypoattenuating cerebral defects with rim enhancement due to cerebral aspergillosis. (c) CT scan obtained 9 days later while the patient was undergoing fungistatic therapy reveals intralesional hemorrhage with intense contrast enhancement. Intracranial aspergillosis was confirmed at autopsy.